Pregledni rad

https://doi.org/10.64266/amu.1.1.10

Vasopressors in Trauma Patients: A Review of Indications, Benefits, and Controversies

Višnja Nesek Adam orcid.org/0000-0002-6521-4136 ; Klinička Bolnica Sveti Duh, Zagreb, Hrvatska *
Adis Keranović ; Klinički Bolnički Centar Zagreb, Zagreb, Hrvatska
Anđela Simić ; Zavod za Hitnu Medicinu Varaždinske Županije, Varaždin, Hrvatska
Martina Matolić ; Klinička Bolnica Sveti Duh, Zagreb, Hrvatska
Tamara Murselović ; Klinička Bolnica Sveti Duh, Zagreb, Hrvatska

* Dopisni autor.

Sažetak

Trauma-induced shock, primarily classified as hypovolemic shock, is a critical condition resulting from significant blood loss or fluid shifts, leading to impaired tissue perfusion and oxygenation. The physiological response to this state involves a two-phase process: an initial activation of the sympathetic nervous system (SNS) to maintain perfusion of vital organs, followed by a later phase characterized by receptor downregulation, metabolic acidosis, and the development of multi-organ dysfunction. The use of vasopressors in trauma-induced shock, particularly norepinephrine, is a common approach to managing hypotension. However, their application remains a subject of ongoing debate due to concerns about their potential impact on microcirculatory flow, tissue perfusion, and endothelial function. The choice of vasopressor, optimal dosing, and timing of initiation are contentious issues, as these factors significantly influence patient outcomes. Further research is essential to refine treatment algorithms and improve the prognosis of critically ill trauma patients.

Ključne riječi

Multi-Organ Dysfunction; Shock; Trauma; Vasopressors

Hrčak ID:

333868

URI

https://hrcak.srce.hr/333868

Datum izdavanja:

1.2.2025.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.880 *