Original scientific paper
Clinical and Sonographic Assessment of Carboxytherapy Efficacy in Treatment of Skin Aging: A 2-split Randomized Clinical Trial
Nooshin Bagherani
; Tehran University of Medical Sciences, Tehran, Iran
Abolfazl Jokar
; Arak University of Medical Sciences, Arak, Markazi Province, Iran
Golshan Mirmomeni
; Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Bruce R Smoller
; University of Rochester School of Medicine and Dentistry, Rochester, United States;
Alireza Ghanadan
; Department of dermatopathology, Razi Hospital and Department of Pathology, Cancer Institute, Imam Khoemini Hospital Complex, Tehran, Iran;
Reza Shojaei
; Arak University of Medical sciences, Arak, Iran
Alireza Firooz
; Center for Research & Training in Skin Diseases & Leprosy, Clinical Trial Center, Tehran University of Medical Sciences, Tehran, Iran;
Roxana Sahebnasagh
; Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
Gholamreza Tavoosidana
; Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
*
* Corresponding author.
Abstract
Introduction: Aging is a continuous and irreversible process which affects the
skin. During the aging process, intrinsic progressive degenerative changes in the
skin impair its structure, which makes it prone to different dermatoses, resulting in
impaired quality of life in the elderly.
Objective: Carboxytherapy is considered as a safe, minimally invasive modality ap-
plied for skin rejuvenation, restoration, and recondition. Herein, we have assessed
the efficacy of carboxytherapy in the treatment of skin aging through clinical and
sonographic studies.
Materials and methods: Our study was a prospective 2-split clinical trial in which
the efficacy of carboxytherapy was assessed in the treatment of abdominal skin
aging through clinical and sonographic evaluations.
Results: Twenty-eight patients with skin-intrinsic aging manifestations in the ab-
domen completed the study. Their mean age was 44.13 years. The mean weight,
BMI, and waist circumference of the subjects significantly decreased after the treat-
ment. The clinical subjective and objective evaluations revealed statistically sig-
nificant improvement of skin wrinkles, laxity, and skin pigmentation and overall
satisfaction by carboxytherapy. Upon sonographic investigation, a significant in-
crease in epidermis and dermis thickness was observed. No significant side-effect
was reported by the subjects.
Conclusion: Carboxytherapy is an effective and safe modality in treating intrinsic
skin aging.
Keywords
skin aging; carboxytherapy; treatment
Hrčak ID:
334828
URI
Publication date:
20.6.2024.
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