Acta clinica Croatica, Vol. 64. No. 1, 2025.
Izvorni znanstveni članak
https://doi.org/10.20471/acc.2025.64.01.06
Serum Phosphorus as a Risk Factor for Cardiovascular Morbidity in Type 2 Diabetes Mellitus Patients
Dajana Katičić
; Division of Nephrology and Dialysis, Department of Internal Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
*
Josipa Josipović
; Division of Nephrology and Dialysis, Department of Internal Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Marko Lucijanić
; Division of Hematology, Department of Internal Medicine, Dubrava University Hospital, Zagreb, Croatia
Tonko Gulin
; Division of Nephrology and Dialysis, Department of Internal Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Marijana Lukšić Puljak
; Nursery Medical School Karlovac, Karlovac, Croatia
Draško Pavlović
; Polyclinic B. Braun Avitum, Zagreb, Croatia
* Dopisni autor.
Sažetak
Phosphorus plays an important role in many physiological functions. Numerous
studies have linked phosphorus concentration to cardiovascular (CV) disease and mortality rates. In this
study, we investigated the association between high-normal serum phosphorus levels and CV morbidity
in patients with type 2 diabetes. Two groups of patients with type 2 diabetes were studied, comprising
both males and females aged 18 years and older. One group (140 subjects) had no CV events, while the
other group (140 subjects) had one or more CV events. In both groups, we collected fasting laboratory
values, medical history, and examination findings. Serum phosphorus levels were statistically significantly
higher in patients with CV events and had statistically significant but relatively modest discriminatory
properties (AUC 0.591; 95% confidence interval (CI) 0.531–0.649; p=0.008). A univariate logistic regression
model of serum phosphorus as a continuous variable revealed a statistically significant association
with the presence of a cardiovascular event (odds ratio (OR) 7.1849, 95% CI 1.7728 - 29.1190;
p=0.0057). For each 1 mmol/L increase in serum phosphorus, the probability of a CV event increased
7.4-fold. After a multivariable logistic regression model, serum phosphorus was associated with a CV
event (p=0.0016, OR 16.6), regardless of age, sex, total cholesterol, and systolic blood pressure.
Ključne riječi
Serum phosphorus; Hyperphosphatemia; Cardiovascular morbidity; Type 2 diabetes mellitus
Hrčak ID:
335487
URI
Datum izdavanja:
31.3.2025.
Posjeta: 646 *