Original scientific paper
https://doi.org/10.51558/2232-7568.2024.17.2.1
Tyrosinase inhibition, antioxidative and antimicrobial activity of active substances and creams used in the treatment of hyperpigmentation (kojic acid, niacinamide and grapevine extract)
Merima Ibišević
; Faculty of Pharmacy, University of Tuzla, Bosnia and Herzegovina
*
Nermina Hadžigrahić
; Faculty of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina
Saša Pilipović
orcid.org/0000-0001-7574-5881
; The Agency for medicinal products and medical devices, Control laboratory of the Agency in Sarajevo, Bosnia and Herzegovina; Faculty of Pharmacy, Tuzla, Bosnia and Herzegovina
Adaleta Softić
; Faculty of Pharmacy, University of Tuzla, Bosnia and Herzegovina
Aida Smajlović
; Faculty of Pharmacy, University of Tuzla, Bosnia and Herzegovina
Nahida Srabović
; Faculty of Pharmacy, University of Tuzla, Bosnia and Herzegovina
Darja Husejnagić
; Faculty of Mathematics and Natural sciences, University of Tuzla
Zahida Ademović
orcid.org/0000-0002-3780-1608
; Faculty of Forestry, University of Sarajevo, Sarajevo, Bosnia and Herzegovina
Emir Horozić
orcid.org/0000-0003-0242-3093
; Faculty of Technology, University of Tuzla, Bosnia and Herzegovina
Enida Karić
; Faculty of Pharmacy, University of Tuzla, Bosnia and Herzegovina
Lamija Kolarević
; Faculty of Pharmacy, University of Tuzla, Bosnia and Herzegovina
Dženeta Akeljić
; Faculty of Pharmacy, University of Tuzla, Bosnia and Herzegovina
Maida Šljivić Husejnović
; Faculty of Pharmacy, University of Tuzla, Bosnia and Herzegovina
Halid Makić
; Biotechnical faculty, University of Bihać, Bihać, Bosnia and Herzegovina
Samira Dedić
; Biotechnical faculty, University of Bihać, Bihać, Bosnia and Herzegovina
* Corresponding author.
Abstract
Hyperpigmentation is a skin disorder caused by increased melanin production. It appears in the form of dark spots and makes the complexion uneven. Pigmentation spots, such as age spots (also known as sun spots), manifest themselves most often on the palms, face and hands. The aim of this work was to investigate and evaluate which of the active substances used in hyperpigmentation treatments has the highest degree of tyrosinase inhibition, and the best antioxidant and antimicrobial activity. Kojic acid, niacinamide and grapevine extract were used as active substances in the formulations. When summarizing the results, kojic acid gave the best results, followed by niacinamide, and finally grapevine extract. However, it is necessary to perform a long-term in vivo study on volunteers that will show the effectiveness and efficiency of the mentioned substances. In addition to the treatment of hyperpigmentation, the mentioned substances can also be used in antiaging skin treatments due to the presence of antioxidant activity.
Keywords
kojic acid; niacinamide; grapevine exctract; hyperpigmentation; tyrosinase inhibition
Hrčak ID:
335775
URI
Publication date:
2.5.2025.
Visits: 598 *