Original scientific paper
https://doi.org/10.3325/cmj.2024.65.417
The effect of 5-alpha reductase inhibitors on the detection of prostate cancer with multiparametric magnetic resonance imaging and prostate biopsy
Mefail Aksu
orcid.org/0000-0001-7490-2793
; Department of Urology, Giresun University School of Medicine, Giresun, Turkey
*
Ural Oğuz
; Department of Urology, Giresun University School of Medicine, Giresun, Turkey
Serdar Aslan
; Department of Radiology, Giresun University School of Medicine, Giresun, Turkey
Erhan Demirelli
; Department of Urology, Giresun University School of Medicine, Giresun, Turkey
Özay Demiray
; Department of Urology, Ministry of Health, Giresun Training and Research Hospital, Giresun, Turkey
Birgül Tok
; Department of Pathology, Giresun University School of Medicine, Giresun, Turkey
Doğan Sabri Tok
; Department of Urology, Giresun University School of Medicine, Giresun, Turkey
Ercan Öğreden
; Department of Urology, Giresun University School of Medicine, Giresun, Turkey
* Corresponding author.
Abstract
Aim To evaluate the effect of 5 alpha-reductase inhibitor
(5-ARI) treatment on prostate cancer detection by multi
-
parametric magnetic resonance imaging (mpMRI).
Methods We retrospectively collected data on 429 pa
-
tients who underwent mpMRI before prostate biopsy in
the Urology Department of Giresun University Training
and Research Hospital between March 2018 and Decem
-
ber 2021. The patients were categorized as those who had
never been treated with 5-ARI (n
=359) and those who
were treated with 5-ARI for more than six months (n
=70).
The two groups were compared in terms of age, mpMRI
findings, and pathology results.
Results The number of patients with Prostate ImagingReporting and Data System (PIRADS) 3 score was significantly higher in the 5-ARI group (37.1% vs 20.6%; P=0.009).
The groups did not differ in terms of malignant pathologi
-
cal findings (48.5% in the non-5-ARI vs 47.1% in the 5-ARI
group;
P
=0.505). The detection rates of malignant patho
-
logical findings in PIRADS 3 and PIRADS 5 patients were
similar between the 5-ARI and non-5-ARI group. However,
malignancy detection rate in PIRADS 4 patients was sig
-
nificantly higher in the non-5-ARI group (
P
=0.031). In the
non-5-ARI group, the sensitivity was 56.4% and the spec
-
ificity was 79.7%. In the 5-ARI group, the sensitivity was
84.9% and the specificity was 56.8%.
Conclusion In patients with suspected prostate cancer,
5-ARI intake may alter lesion mpMRI characteristics and
PIRADS distribution on mpMRI. 5-ARI intake should be re
-
ported to the radiologist.
Keywords
Hrčak ID:
336485
URI
Publication date:
15.10.2024.
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