Pregledni rad

Migraines: unraveling the mystery

Lukas Librić ; Medicinski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska *

* Dopisni autor.

Sažetak

Migraine is a prevalent and complex neurological disorder that significantly impacts the quality of life of affected individuals. This paper explores the pathophysiology, classification, and treatment options for migraine. The disorder is characterized by altered sensory processing and heightened susceptibility, with an apparent gender disparity, affecting 18% of women and 6% of men. Pathogenesis involves abnormal cortical processing and mitochondrial dysfunction, ultimately leading to the overexcitation of the trigeminovascular system, neurogenic inflammation, and vasodilation. Migraine is classified into three subtypes: migraine with aura, migraine without aura, and chronic migraine, each with distinct phases such as prodrome, aura, headache, and postdrome. The diagnosis relies on these clinical presentations and symptom patterns. Non-pharmacological treatments, including lifestyle modifications, stress management, and physical therapy, play an essential role in preventing chronic migraine development. Pharmacological therapies, such as over-the-counter medications, triptans, and newer treatments like ditans and gepants, are effective in alleviating migraine symptoms. This paper highlights the importance of a comprehensive and individualized treatment approach for managing migraine and improving patient outcomes.

Ključne riječi

headache; migraine; neurology; pharmacology; review literature

Hrčak ID:

343398

URI

https://hrcak.srce.hr/343398

Datum izdavanja:

28.12.2025.

Posjeta: 377 *