Pregledni rad

https://doi.org/10.21860/medflum2026_343561

Clozapine Use in Children and Adolescents: A Literature Review and a Case Report from Croatia

Dinko Horvat orcid.org/0009-0004-4188-2457 ; Klinički bolnički centar Zagreb, Klinika za dječju i adolescentsku psihijatriju, Zagreb, Hrvatska *
Petra Visković ; Klinički bolnički centar Zagreb, Klinika za dječju i adolescentsku psihijatriju, Zagreb, Hrvatska
Marta Okružnik Želalić orcid.org/0009-0002-9067-5636 ; Klinički bolnički centar Zagreb, Klinika za dječju i adolescentsku psihijatriju, Zagreb, Hrvatska
Ivana Stefanović orcid.org/0009-0006-8213-4652 ; Klinički bolnički centar Zagreb, Klinika za dječju i adolescentsku psihijatriju, Zagreb, Hrvatska
Mara Tripković orcid.org/0009-0007-8239-614X ; Klinički bolnički centar Zagreb, Klinika za dječju i adolescentsku psihijatriju, Zagreb, Hrvatska; Sveučilište u Dubrovniku, Studij sestrinstvo i kliničko sestrinstvo, Dubrovnik, Hrvatska
Gordan Majić ; Klinički bolnički centar Zagreb, Klinika za dječju i adolescentsku psihijatriju, Zagreb, Hrvatska; Sveučilište u Zagrebu, Medicinski fakultet, Zagreb, Hrvatska

* Dopisni autor.

Sažetak

Clozapine is the only antipsychotic with proven superiority in the treatment of treatment-resistant schizophrenia (TRS), yet its use in children and adolescents, to our knowledge, is rare both in the world and in Croatia. Despite growing evidence of its efficacy, its prescription is often delayed due to concerns about side effects and the need for intensive monitoring. To our knowledge, the literature in Croatia lacks published research and case reports that could serve as guidelines for clinical practice, which further complicates the timely introduction of this effective therapy in children and adolescents. This review examines the available evidence on the efficacy and safety of clozapine in the paediatric population, including its pharmacological mechanisms, therapeutic potential, and adverse effects. Additionally, a clinical case of an adolescent with treatment-resistant disorganized schizophrenia is presented, demonstrating clinical improvement following clozapine administration. Despite its well-documented superiority in TRS, clozapine remains underutilized in paediatric psychiatry.

Ključne riječi

adolescent psychiatry; case reports; child psychiatry; clozapine; schizophrenia; treatment

Hrčak ID:

343561

URI

https://hrcak.srce.hr/343561

Datum izdavanja:

1.3.2026.

Podaci na drugim jezicima: hrvatski

Posjeta: 326 *