Izvorni znanstveni članak

https://doi.org/10.24869/psyd.2025.310

The effect of olanzapine on IGF-1/IGF-1R and volumes in the prefrontal cortex and hippocampus in a model of bipolar mania

Eser Çakmak ; Medical Biochemistry Department, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey
Özgür Korhan Tunçel ; Medical Biochemistry Department, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey
Mehmet Emin Önger ; Histology and Embryology Department, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey

Sažetak

Background: The aim of the study is to determine the changes in insulin-like growth factor 1 (IGF-1) and its receptor (IGF-1R) in the emergence of bipolar disorder and its treatment with olanzapine.
Subjects and Methods: Of all 48 adult male albino wistar rats, the control group (n=12) saline, ketamine group (n=12) ketamine (25mg/kg), olanzapine group (n=12) olanzapine (2mg/kg), ketamine+olanzapine group (n=12) ketamine (25 mg/kg) was administered once a day/14 days. Olanzapine (2mg/kg) was administered once a day to the ketamine+olanzapine group between 8 and 14 days. Volume, IGF-1, and IGF-1R gene expression and protein levels were measured in the prefrontal cortex and hippocampus.
Results: In the prefrontal cortex, there was a decrease in volume, IGF-1R gene expression, and protein levels in the ketamine group, an increase in IGF-1 gene expression and protein levels in the olanzapine group; an increase in IGF-1R gene expression, IGF-1, and IGF-1R protein levels in the ketamine+olanzapine group. In hippocampus, there was a decrease in volume, IGF-1 gene expression and protein levels in ketamine group, a decrease in volume and IGF-1 protein levels, increase in IGF-1R gene expression and protein levels in olanzapine group; a decrease in volume, IGF-1 protein levels and IGF-1R gene expression and protein levels in ketamine+olanzapine group.
Conclusions: One of the underlying causes of bipolar disorder may be changes in the IGF-1 and IGF-1R regions in the prefrontal cortex and hippocampus. Olanzapine has a neuroprotective effect by increasing IGF-1 and IGF-1R levels in the prefrontal cortex, and a neurodegenerative effect by decreasing IGF-1 and IGF-1R levels in the hippocampus.

Ključne riječi

Olanzapine; IGF-1; IGF-1R; Prefrontal cortex; Hippocampus

Hrčak ID:

344031

URI

https://hrcak.srce.hr/344031

Datum izdavanja:

4.12.2025.

Posjeta: 171 *