Pregledni rad
Migraine in Men
Davor Jančuljak
Sažetak
Migraine in men, although less common than in women, represents a significant and often underdiagnosed neurological disorder. The prevalence in adult men is approximately 6–8%, with sex-related differences in occurrence and clinical course changing with age. In childhood, prevalence is similar between boys and girls, while after puberty it rises sharply in girls but remains stable in boys. Men more frequently report physical exertion, alcohol, and stress as triggers, whereas hormonal triggers are rare. Pathophysiologically, men exhibit more stable trigeminovascular activity, lower modulation of serotonergic and calcitonin gene-related peptide (CGRP) pathways, and distinct patterns of brain activation, which may explain shorter attacks and milder associated symptoms such as photophobia, phonophobia, and nausea. Clinical presentation includes more frequent unilateral, intense pain, shorter attack duration, and fewer accompanying vegetative symptoms. Men more commonly present with cardiovascular and metabolic comorbidities, while psychiatric disorders are more prevalent in women. Pharmacological and non-pharmacological treatments show similar efficacy in both sexes, but men are more adherent to preventive therapy and more likely to employ active self-management strategies. Understanding sex-specific characteristics of migraine is crucial for timely diagnosis, individualized therapeutic approaches, and reducing the risk of chronification and complications.
Ključne riječi
migraine, gender differences, male gender
Hrčak ID:
345182
URI
Datum izdavanja:
26.2.2026.
Posjeta: 380 *