Izvorni znanstveni članak
https://doi.org/10.21857/moxpjh72jm
Renal denervation improves metabolic disturbances and inflammation with positive impact on kidney function in patients with resistant and difficult-to-control hypertension in long-term follow up
Barišić Klara
Jelaković Ana
Luka Šimunović
Dražen Perkov
Josipa Josipović
Ingrid Prkačin
Marijana Živko
Tajana Željković Vrkić
Marija Domislović
Lana Gellineo
Jelena Kos
Ivana Vuković Brinar
Emal Ivandić
Mila Lovrić
Ivan Pećin
Bojan Jelaković
Sažetak
Introduction: The aim of this study was to examine the effects of catheter renal denervation (RDN) on blood pressure (BP), inflammatory and metabolic biomarkers and kidney function in patients with resistant and difficult-to-control hypertension during an average 33-month follow-up. Materials and Methods: The analysis included 27 out of 125 patients from the Croatian Registry for RDN. Office BP and ABPM were performed before and during the follow-up period. In addition to classic metabolic parameters and determination of kidney function, evaluation of new biomarkers was performed (neutrophil-to-lymphocyte ratio (NLR), triglyceride-to-glucose index (TyGi) and triglyceride-to-HDL cholesterol ratio (TG/HDL)). Results: A significant reduction in BP was observed after RDN which was accompanied by significant decrease in total and LDL cholesterol, triglycerides and fasting blood glucose, as well as with the improvement of kidney function. In addition, there was a significant decrease in NLR (p=0.037), TyGi (p=0.006) and TG/HDL (p=0.068). A decrease in these biomarkers indicates an improvement in systemic inflammation and metabolic profile.
Conclusions: RDN significantly reduces BP and has a favorable effect on biomarkers of inflammation and metabolic risk as well as on kidney function in patients with resistant and difficult-to-control hypertension. These results indicate that RDN may contribute to overall cardiovascular risk reduction independent of effect on BP.
Ključne riječi
Renal denervation; hypertension; dyslipidemia; biomarkers
Hrčak ID:
346147
URI
Datum izdavanja:
28.12.2025.
Posjeta: 232 *