Medicina Fluminensis, Vol. 62 No. 2, 2026.
Pregledni rad
https://doi.org/10.21860/medflum2026_346494
Subcutaneous Ossification as a Rare Complication of Chronic Venous Insufficiency
Marinko Filipović
; Clinical Hospital Center Rijeka, Clinic for Surgery, Department of Vascular Surgery, Rijeka, Croatia
*
Vilma Grbas Kranjčević
; Clinical Hospital Center Rijeka, Clinic for Dermatovenereology, Rijeka, Croatia
Domagoj Ćužić
; Clinical Hospital Center Rijeka, Clinic for Dermatovenereology, Rijeka, Croatia
Domagoj Mihaljević
; Clinical Hospital Center Rijeka, Clinic for Surgery, Department of Vascular Surgery, Rijeka, Croatia
Mari Rončević Filipović
; Clinical Hospital Center Rijeka, Clinic for Infectious Diseases, Rijeka, Croatia
Tomislav Novinšćak
; County Hospital Čakovec, Department of General Surgery, Vascular Surgery and Urology, Čakovec, Croatia
Harry Grbas
; University Hospital Centre Rijeka, Clinic for Surgery, Department of Digestive Surgery, Rijeka, Croatia
Mario Barukčić
; Institute of Emergency Medicine of Brod-Posavina County, Slavonski Brod, Croatia
* Dopisni autor.
Sažetak
Chronic venous insufficiency is a condition caused by dysfunction of the venous valves, which hinders venous blood return and increases hydrostatic pressure. This can lead to the appearance of telangiectasia, varicose veins, hyperpigmentation, eczema, lipodermatosclerosis, and in more severe cases, venous ulcers. Long-term chronic venous insufficiency can lead to a rare complication - subcutaneous ossification, which was first described by Lippman in 1957. Dystrophic calcification, which occurs in chronic venous insufficiency, causes deposition of calcium in the subcutaneous tissue, which can interfere with ulcer healing and contribute to the development of heterotopic ossification. Heterotopic ossification is an abnormal formation of bones in the extraskeletal tissue, which most often occurs after trauma, orthopaedic procedures or in neurological disorders. Although the exact mechanism of heterotopic ossification development in chronic venous insufficiency is not fully elucidated, research indicates that inflammatory processes and increased activity of alkaline phosphatase can lead to calcium accumulation, leading to the formation of bone structures. In patients with venous insufficiency, calcifications most often appear as phleboliths, with a characteristic appearance on X-rays. Histologically, heterotopic ossification shows a zonal bone structure with a peripheral area of ossification, while in later stages it resembles a normal bone structure. Treatment includes surgical removal as the optimal method, while conservative treatments such as sodium thiosulfate and etidronate can be used to slow the progression of calcifications.
Ključne riječi
leg ulcer; metaplasia; ossification; venous insufficiency
Hrčak ID:
346494
URI
Datum izdavanja:
1.6.2026.
Posjeta: 0 *