Studija slučaja
A Rare Case of Paraneoplastic Raynaud’s Phenomenon and Uveal Melanoma
Lara Vasari
; Special Hospital for Medical Rehabilitation Naftalan, Ivanić-Grad, Croatia
Sanda Špoljarić Carević
; Special Hospital for Medical Rehabilitation Naftalan, Ivanić-Grad, Croatia
*
Lucija Tomić Babić
; Special Hospital for Medical Rehabilitation Naftalan, Ivanić-Grad, Croatia
Marija Bakula
; University Hospital Center Zagreb, Zagreb, Croatia
* Dopisni autor.
Sažetak
Raynaud’s phenomenon (RP) presents as acral skin pallor, cyanosis, and erythema,
usually after cold exposure or emotional stress. Symptoms of RP affect 3-5% of
the general population, with the incidence four times higher in women than in men.
Paraneoplastic RP is extremely rare and is thought to involve plasma hyperviscosity and
blood hypercoagulability, which are present in patients with malignant diseases. Paraneoplastic
RP often presents abruptly and, besides changes in skin color, it includes erosions,
ulcerations, and necrosis, resulting in severe pain. We present a case of a 62-yearold
female patient who suddenly developed symptoms of RP, characterized by periodic
skin pallor without erosions or associated pain in all fingers, lasting 10-15 minutes after
cold exposure. She was diagnosed with uveal melanoma three months prior and was
also in a 14-year remission from invasive ductal carcinoma. Investigations confirmed
positive antinuclear antibodies (ANA) with PCNA (proliferating cell nuclear antigen) and
myositis-specific antibodies including anti-Jo, anti-mitochondrial antibody (AMA-M2),
and anti-benzylpenicilloyl antibody (BPO).
Ključne riječi
Raynaud’s phenomenon; uveal melanoma,; paraneoplastic syndrome
Hrčak ID:
346658
URI
Datum izdavanja:
10.4.2025.
Posjeta: 12 *