Pregledni rad
https://doi.org/10.66166/cjaim.2.1.2
Ketamine and Spine Surgery – Review
Ivan Krezić
; Department of Anesthesiology and ICU, University Hospital Centre Zagreb, Zagreb, Croatia
*
Marin Lozić
; Department of Anesthesiology and ICU, University Hospital Centre Zagreb, Zagreb, Croatia
Marijana Matas
; Department of Anesthesiology and ICU, University Hospital Centre Zagreb, Zagreb, Croatia
Nikša Perić
; Department of Anesthesiology and ICU, University Hospital Centre Zagreb, Zagreb, Croatia
Vasilije Stambolija
; Department of Anesthesiology and ICU, University Hospital Centre Zagreb, Zagreb, Croatia
Miroslav Šćap
; Department of Anesthesiology and ICU, University Hospital Centre Zagreb, Zagreb, Croatia
* Dopisni autor.
Sažetak
INTRODUCTION: Various multimodal analgesic approaches have been proposed for spine surgery. This article aims to review
the evidence regarding the effect of perioperative ketamine on postoperative opioid consumption, pain
scores, and side effects.
MATERIALS AND METHODS: We included clinical trials in the adult population. Our primary outcome was pain management. Randomized controlled trials published in the English language from January 1995 to September 2025 assessing post
operative pain after spine surgery were identified from the MEDLINE database.
RESULTS: A total of 16 clinical trials were selected for inclusion in the Review.
CONCLUSION: Perioperative low doses of ketamine demonstrated analgesic and opioid-sparing effects with no increased
adverse events after spine surgery. Further studies of qualitative randomized controlled trials are required to
assess the optimal protocol of ketamine administration for postoperative pain relief
Ključne riječi
ketamine; spine surgery; opioids; pain management
Hrčak ID:
348889
URI
Datum izdavanja:
6.7.2026.
Posjeta: 0 *