Socijalna psihijatrija, Vol. 54 No. 2, 2026.
Sažetak sa skupa
https://doi.org/10.24869/spsih.2026.153
Vitamin D and Cognitive Domains in Patients With Mild Cognitive Impairment and Dementias
Hanna Pašić
; Klinika za psihijatriju, Klinički bolnički centar „Sestre milosrdnice“, Vinogradska cesta 29, 10000 Zagreb, Hrvatska
*
Frane Paleka
; Klinika za psihijatriju, Klinički bolnički centar „Sestre milosrdnice“, Vinogradska cesta 29, 10000 Zagreb, Hrvatska
Dalibor Karlović
; Klinika za psihijatriju, Klinički bolnički centar „Sestre milosrdnice“, Vinogradska cesta 29, 10000 Zagreb, Hrvatska; Medicinski fakultet, Hrvatsko katoličko sveučilište, Ilica 244, 10000 Zagreb, Hrvatska
* Dopisni autor.
Sažetak
Introduction: Lower vitamin D concentrations
are associated with poorer cognitive outcomes,
but findings from previous studies have been inconsistent.
Since global screening tests may fail
to detect more subtle differences between specific
cognitive domains, the aim of this study was
to examine the association of serum vitamin D
with global cognitive status and individual cognitive
domains in patients with mild cognitive
impairment, Alzheimer’s dementia, and vascular
dementia. Subjects and methods: A retrospective
cross-sectional study was conducted on
108 patients of the Day Hospital for Dementia
at the Clinic for Psychiatry, University Hospital
Centre Zagreb. The sample included patients
with Alzheimer’s dementia, vascular dementia,
and mild cognitive impairment. Global cognitive
functioning was assessed using the MMSE and MoCA tests, while individual cognitive domains
were evaluated with the 5-Cog test. The domains
analyzed were memory, verbal fluency, executive
functions, information processing speed, and
working memory. Results: The mean vitamin D
concentration was 62.8 nmol/L. A positive association
was found between vitamin D and memory
(r = 0.55; p < 0.001). A weaker but statistically
significant association was observed for verbal
fluency (r = 0.25; p = 0.010) and executive functions
(r = 0.23; p = 0.018). No significant association
was found between vitamin D and MMSE
or MoCA scores. The association between vitamin
D and memory remained stable after controlling
for age and education, as well as after excluding
participants with extremely high vitamin D values.
Vitamin D status did not differ significantly
between diagnostic groups. Conclusion: Serum
vitamin D was associated primarily with specific
cognitive domains, particularly memory, while no
association was found with global screening test
scores. The results highlight the importance of assessing
individual cognitive domains in patients
with neurocognitive disorders, given that global
screening tests may not be sufficiently sensitive
to detect associations between biological factors
and cognitive functioning.
Ključne riječi
vitamin D; cognitive domains; dementia; memory
Hrčak ID:
352269
URI
Datum izdavanja:
15.6.2026.
Posjeta: 0 *