Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2026.67.14
Effects of craniectomy on cerebrospinal fluid pressure gradient in the craniospinal space in different body positions of cats
Marijan Klarica
; Department of Pharmacology, Zagreb University School of Medicine, Zagreb, Croatia
Gorislav Erceg
; Department of Pharmacology and Croatian Institute for Brain Research, Zagreb University School of Medicine, Zagreb, Croatia
Sergej Mihailovič Marasanov
; Department of Neurosurgery, Unit for Functional and Stereotactic Neurosurgery and Radiosurgery, Zagreb University Hospital Center, Zagreb, Croatia
*
Milan Radoš
; Croatian Institute for Brain Research, University of Zagreb School of Medicine and Clinical Department of Diagnostic and Interventional Radiology, Zagreb University Hospital Center, Zagreb, Croatia
Filip Njavro
; Clinical Department of Diagnostic and Interventional Radiology, Zagreb University Hospital Center, Zagreb, Croatia
Darko Orešković
; Department of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia
Ivana Jurjević
; Department of Neurology, Zagreb University Hospital Center, Zagreb University School of Medicine, Zagreb, Croatia
* Dopisni autor.
Sažetak
Aim To assess whether a cranial defect in anesthetized cats
alters cerebrospinal fluid (CSF) pressure distribution across
the craniospinal axis in different body positions in the set
ting of intracranial normotension.
Methods After standardized parietal craniectomy, intrac
ranial and lumbar CSF pressures were simultaneously mea
sured in eight adult anesthetized (α-chloralose, i.p. 100 mg/
kg) cats in different body positions: horizontal (0°), head-up
(45°; 90°), and head-down (225°; 270°). CSF pressure gradi
ent represents the difference between CSF pressure values
in the lateral ventricle (LV) and lumbar subarachnoid space
(LSS) in each body position.
Results At 0°, CSF pressures in the LV and LSS were sim
ilar (16.2 ± 0.9 vs 15.8 ± 1.2 cm H2
O, respectively). In the
90° head-up position, LV pressure was subatmospheric
(−1.5 ± 0.5 cm H2
O), while LSS pressure simultaneously in
creased (31.4 ± 1.0 cm H2
O). Conversely, in the head-down
270° position, LSS pressure was negative (−1.7 ± 1.5 cm
H2
O) and LV pressure increased (30.0 ± 1.8 cm H2
O). Dif
ference between LV and LSS pressures is strongly corre
lated with hydrostatic difference between the two record
ing points in the head-up and the head-down position. LV
pressure at 90° in the craniectomy group was significantly
higher than previously published in cats with an intact cra
nium in the same position (P < 0.001).
Conclusion Hydrostatic CSF pressure gradient across the
craniospinal axis remained unaltered by craniectomy. The
finding that craniectomy in the head-up position of ani
mals without intracranial pathology resulted in an intracra
nial pressure increase may offer additional explanation for
the trephined syndrome pathophysiology.
Ključne riječi
Hrčak ID:
352577
URI
Datum izdavanja:
25.2.2026.
Posjeta: 0 *