Biochemia Medica, Vol. 19 No. 3, 2009.
Izvorni znanstveni članak
Hematological markers of anemia and C-reactive protein in patients with stable chronic obstructive pulmonary disease
Dolores Pancirov
; Odjel za biokemijsko-hematološku dijagnostiku, Opća bolnica „Dr. Ivo Pedišić”, Sisak, Hrvatska
Vanja Radišić Biljak
; Medicinsko-biokemijski laboratorij, Poliklinika „Sunce", Zagreb, Hrvatska
Gordana Stjepanović
; Pulmološki odjel, Opća bolnica„Dr. Ivo Pedišić", Sisak, Hrvatska
Ivana Čepelak
; Zavod za medicinsku biokemiju i hematologiju Farmaceutsko-biokemijskog fakulteta Sveučilišta u Zagrebu, Zagreb, Hrvatska
Sažetak
Background: The aim of the study was to determine the values of hematological markers of anemia and of C-reactive protein (CRP) in patients with stable chronic obstructive pulmonary disease (COPD) in order to define the presence of anemia, degree of systemic inflammation and correlations between the analytes.
Material and methods: The study included 150 COPD patients (FEV1 = 48 ± 21%) and 51 control subjects (FEV1 = 106 ± 15%). Pursuant to GOLD guidelines, the patients were divided into four subgroups and according to WHO criteria for anemia into two subgroups: subjects with and those without anemia. Serum CRP concentration was determined by immunoturbidimetric method and hematological markers were determined by flow cytometry.
Results: No significant differences were found in the values of erythrocytes, hemoglobin and hematocrit either between the group of all COPD patients and control subjects or between GOLD subgroups and control subjects. Anemia was present in 24% of COPD patients. CRP concentration was significantly higher in the group of all COPD patients, in all GOLD subgroups (I, IIA, IIB and III) and in subgroups with and without anemia as compared to control subjects (P < 0.001 all). CRP specificity and sensitivity were determined by ROC analysis and showed good diagnostic accuracy for CRP in COPD patients. Correlation coefficient between CRP and hemoglobin and hematocrit values revealed a good negative correlation (r = -0.60 and r = -0.59, respectively; P < 0.001 both) only in GOLD subgroup III.
Conclusion: CRP concentration, a marker of systemic inflammation, was signiVcantly higher in COPD patients and in all GOLD subgroups as compared to the control group. Good negative correlation was recorded between hematocrit and hemoglobin values and advanced inflammation (CRP concentration) in GOLD subgroup III. The rate of anemia was in agreement with literature data.
Ključne riječi
chronic obstructive pulmonary disease; anemia; C-reactive protein; GOLD guidelines
Hrčak ID:
40856
URI
Datum izdavanja:
24.9.2009.
Posjeta: 2.377 *