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CATECHOL-O-METHYL TRANSFERASE AND SCHIZOPHRENIA

Marina Šagud orcid.org/0000-0001-9620-2181 ; Medicinski fakultet Sveučilišta u Zagrebu, Odjel psihijatrije, Sveučilišna bolnica Zagreb, Hrvatska
Dorotea Műck-Šeler ; Odjel molekularne medicine, Institut Ruđera Boškovića, Bijenička 54, Zagreb, Hrvatska
Alma Mihaljević-Peleš ; Medicinski fakultet Sveučilišta u Zagrebu, Odjel psihijatrije, Sveučilišna bolnica Zagreb, Hrvatska
Bjanka Vuksan-Ćusa ; Medicinski fakultet Sveučilišta u Zagrebu, Odjel psihijatrije, Sveučilišna bolnica Zagreb, Hrvatska
Maja Živković ; Neuropsihijatrijska bolnica
Miro Jakovljević ; Medicinski fakultet Sveučilišta u Zagrebu, Odjel psihijatrije, Sveučilišna bolnica Zagreb, Hrvatska
Nela Pivac ; Odjel molekularne medicine, Institut Ruđera Boškovića, Bijenička 54, Zagreb, Hrvatska

Sažetak

Catechol-O-methyl transferase (COMT) is an enzyme involved in the degradation of dopamine. The most commonly examined polymorphism within the COMT gene is Val108/158Met polymorphism, which results in three to fourfold difference in COMT
enzyme activity. It is particularely important in prefrontal cortex, since COMT activity is the most important regulator of the prefrontal dopamine function. Given the association between schizophrenia and decreased dopamine activity in the prefrontal cortex, it is not surprising that Val108/158Met polymorphism is among the most extensively investigated polymorphisms in schizophrenia. According to different studies, Val allele may be a small risk factor for schizophrenia. There is also some evidence that Val108/158Met polymorphism influences the age of onset of schizophrenia, cognitive function, severity of psychotic symptoms, as well as efficacy and adverse events of antipsychotics. Heterogenity of patient population has undoubtedly influenced the results of these studies. Interaction of Val108/158Met polymorphism with other genes and environmental factors is an important avenue for future research.

Ključne riječi

COMT Val108/158Met polymorphism; schizophrenia; response to antipsychotics

Hrčak ID:

55697

URI

https://hrcak.srce.hr/55697

Datum izdavanja:

30.6.2010.

Posjeta: 1.907 *