Review article

Protumor effects of proinflammatory mediators in breast cancer

MAJA SIROTKOVIĆ-SKERLEV ; Department of Pathophysiology, School of Medicine, University of Zagreb, University Hospital Center Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia
ANA KULIĆ ; Division of Oncology, iversity Hospital Center Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia
LADA BRADIĆ ; Division of Oncology, iversity Hospital Center Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia
TAMARA ČAČEV ; Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička c.54,10000 Zagreb, Croatia

Abstract

Inflammation is defined as an enabling characteristic of malignant
growth. Many proinflammatory mediators have protumor capabilities. In
this review we focus on the protumor effect of cytokines and chemokines in breast cancer. We discuss the role of interleukin 1β, interleukin 6, tumor necrosis factor α, CCL2, CCL5, and CXCL12 and its receptor CXCR4 as typical mediators implicated in breast cancer progression. We also analyze the impact of transcription factor NF-κB. Proinflammatory mediatorswith protumor effects should be considered as therapeutic targets in breast cancer. It is challenging how to find optimal anti-cytokine and anti-chemokine regiments as a part of anticancer therapy.

Keywords

breast cancer; cytokines; chemokines

Hrčak ID:

101251

URI

https://hrcak.srce.hr/101251

Publication date:

30.9.2012.

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