Croatica Chemica Acta, Vol. 86 No. 2, 2013.
Original scientific paper
https://doi.org/10.5562/cca2064
Synthesis and In vitro Antimicrobial Activity of Novel 2-(4-(Substituted-carboxamido)benzyl / phenyl)benzothiazoles
Serap Yilmaz
; Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100, Tandoğan, Ankara, Turkey
Ismail Yalcin
; Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100, Tandoğan, Ankara, Turkey
Fatma Kaynak-Onurdag
; Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Microbiology, 06330, Etiler, Ankara, Turkey
Ilkay Yildiz
; Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100, Tandoğan, Ankara, Turkey
Esin Aki
; Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100, Tandoğan, Ankara, Turkey
Abstract
A new series of 2-[4-(4-substitutedbenzamido / phenylacetamido / phenylpropionamido) benzyl
/ phenyl]benzothiazole derivatives (6a−6w) were synthesized and evaluated for antibacterial and antifungal
activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas
aeruginosa, Escherichia coli with their drug-resistant isolates and a yeast Candida albicans. Microbiological
results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms
at MIC values between 200 and 6.25 μg/ml. Compounds 6e and 6j exhibited the greatest activity
with MIC values of 6.25 μg/ml against Pseudomonas aeruginosa, and Staphylococcus aureus isolate,
respectively.(doi: 10.5562/cca2064)
Keywords
benzothiazole; antibacterial activity; antifungal activity; multi-drug resistance
Hrčak ID:
105598
URI
Publication date:
1.7.2013.
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