Izvorni znanstveni članak

https://doi.org/10.5562/cca2064

Synthesis and In vitro Antimicrobial Activity of Novel 2-(4-(Substituted-carboxamido)benzyl / phenyl)benzothiazoles

Serap Yilmaz ; Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100, Tandoğan, Ankara, Turkey
Ismail Yalcin ; Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100, Tandoğan, Ankara, Turkey
Fatma Kaynak-Onurdag ; Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Microbiology, 06330, Etiler, Ankara, Turkey
Ilkay Yildiz ; Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100, Tandoğan, Ankara, Turkey
Esin Aki ; Ankara University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 06100, Tandoğan, Ankara, Turkey

Sažetak

A new series of 2-[4-(4-substitutedbenzamido / phenylacetamido / phenylpropionamido) benzyl
/ phenyl]benzothiazole derivatives (6a−6w) were synthesized and evaluated for antibacterial and antifungal
activities against Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas
aeruginosa, Escherichia coli with their drug-resistant isolates and a yeast Candida albicans. Microbiological
results indicated that the compounds possessed a broad spectrum of activity against the tested microorganisms
at MIC values between 200 and 6.25 μg/ml. Compounds 6e and 6j exhibited the greatest activity
with MIC values of 6.25 μg/ml against Pseudomonas aeruginosa, and Staphylococcus aureus isolate,
respectively.(doi: 10.5562/cca2064)

Ključne riječi

benzothiazole; antibacterial activity; antifungal activity; multi-drug resistance

Hrčak ID:

105598

URI

https://hrcak.srce.hr/105598

Datum izdavanja:

1.7.2013.

Posjeta: 2.560 *