Review article

https://doi.org/10.5599/admet.2.3.22

Use of voltammetry for in vitro equilibrium and transport studies of ionisable drugs

Matej Velicky orcid.org/0000-0003-4230-3811 ; School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK
Andrew N.J. Rodgers ; School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK
Robert A.W. Dryfe ; School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK
Kin Tam ; Faculty of Health Science, University of Macau, Macau, China

Abstract

In this review, we will briefly outline the voltammetric investigations of the transfer of ionisable drugs at the interface between two immiscible electrolyte solutions. The voltammetric techniques enable the determination of some key in vitro properties of ionisable drugs, including partition coefficient, diffusion coefficient and membrane permeability. Some successful applications will be highlighted, together with the background methodologies.

Keywords

Cyclic voltammetry; partition coefficient; diffusion coefficient; permeability; ITIES

Hrčak ID:

127035

URI

https://hrcak.srce.hr/127035

Publication date:

16.9.2014.

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