Review article

Molecular stratification of colorectal cancer

Sanja Kapitanović orcid.org/0000-0001-8788-3085

Abstract

Colorectal cancer (CRC) is one of the most common cancers and one of the leading causes of cancer death in the Western world. The disease arises from the accumulation of mutations in oncogenes, tumor suppressor genes and mismatch repair genes during progression from normal colon epithelium to adenoma and metastatic carcinoma. Improved understanding of genetic events that underline tumor development and progression may contribute to new strategies for prevention, diagnosis as well as for therapy. The results of Human genome project showed that each person has its unique genetic “signature” as a consequence of a large number of inherited genetic variations. There are also sporadic molecular changes specific for each tumor type. This mini review will give some information about the most frequent molecular genetics changes in colorectal cancer and its molecular stratification due to its heredity, germline pharmacogenetic markers, somatic mutations and microsatellite instability.

Keywords

colorectal cancer; biomarkers; molecular stratification

Hrčak ID:

139036

URI

https://hrcak.srce.hr/139036

Publication date:

14.5.2015.

Article data in other languages: croatian

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