Original scientific paper

Synthesis and biological activity of substituted 2,4,6-s-triazines

VINOD KUMAR PANDEY
SARAH TUSI
ZEHRA TUSI
MADHAWANAND JOSHI
SHASHIKALA BAJPAI

Abstract

Reaction of 7-hydroxy-4-methyl coumarin with amido/imido alcohols in ethanol containing concentrated hydrochloric acid afforded 8-aralkyl amido/imido-alkyl-7-hydroxy-4-methyl-coumarins (1a-f). Interaction of 1a-f with hydrazine hydrate in pyridine resulted in 1-amino-8-aralkyl amido/imido-alkyl-7-hydroxy-4-methyl-2-oxo-quinolines (2a-f). Treatment of 2 with formaldehyde in ethanol resulted in 1,3,5-tris-(8-aralkyl amido/imido-alkyl-7-hydroxy-4-methyl-2-oxo-quinolinyl)-2,4,6-hexahydro-s-triazines (3a-c). Antiviral activity of compounds 2a-d and 3a, 3b upon Japanese encephalitis virus (JEV) and Herpes simplex virus-1 (HSV-1) was evaluated on vero cells in vitro. 3a-c were also screened for their antihypertensive activity.

Keywords

substituted 2,4,6-s-triazines; antiviral activity; antihypertensive activity

Hrčak ID:

16657

URI

https://hrcak.srce.hr/16657

Publication date:

1.3.2004.

Article data in other languages: croatian

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