Acta Pharmaceutica, Vol. 54 No. 1, 2004.
Izvorni znanstveni članak
Synthesis and biological activity of substituted 2,4,6-s-triazines
VINOD KUMAR PANDEY
SARAH TUSI
ZEHRA TUSI
MADHAWANAND JOSHI
SHASHIKALA BAJPAI
Sažetak
Reaction of 7-hydroxy-4-methyl coumarin with amido/imido alcohols in ethanol containing concentrated hydrochloric acid afforded 8-aralkyl amido/imido-alkyl-7-hydroxy-4-methyl-coumarins (1a-f). Interaction of 1a-f with hydrazine hydrate in pyridine resulted in 1-amino-8-aralkyl amido/imido-alkyl-7-hydroxy-4-methyl-2-oxo-quinolines (2a-f). Treatment of 2 with formaldehyde in ethanol resulted in 1,3,5-tris-(8-aralkyl amido/imido-alkyl-7-hydroxy-4-methyl-2-oxo-quinolinyl)-2,4,6-hexahydro-s-triazines (3a-c). Antiviral activity of compounds 2a-d and 3a, 3b upon Japanese encephalitis virus (JEV) and Herpes simplex virus-1 (HSV-1) was evaluated on vero cells in vitro. 3a-c were also screened for their antihypertensive activity.
Ključne riječi
substituted 2,4,6-s-triazines; antiviral activity; antihypertensive activity
Hrčak ID:
16657
URI
Datum izdavanja:
1.3.2004.
Posjeta: 2.407 *