Case report

Primary bilateral renal diffuse large B-cell lymphoma with central nervous system metastases in a captive brown bear (Ursus arctos) - a case report.

Ana Beck orcid.org/0000-0003-4693-3570 ; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Slaven Reljić ; Department of Biology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Ivan-Conrado Šoštarić-Zuckermann ; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Marcin Wrzosek ; Department of Internal Medicine and Clinic of Horses, Dogs and Cats, Faculty of Veterinary Medicine, University of Environmental and Life Sciences, Wroclaw, Poland
Doroteja Huber ; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia

Abstract

We present the first report of primary bilateral renal diffuse large B-cell lymphoma with central nervous system metastases, in a 7 year-old, captive female brown bear. After 7 months of progressive neurological disease, the animal was euthanized. On necropsy, neoplastic nodules with infiltrative growth in the kidneys were found. Neoplastic proliferation of a similar pattern was found compressing the cerebellum and brain stem, and growing through the nervus maxillaris and nervus ophtalmicus. Histology revealed a highly cellular round cell neoplasm, with an infiltrative diffuse growth pattern through the kidneys and nervous parenchyma. On immunohistochemistry, the neoplastic cells stained for the B-cell marker Pax-5. Our report suggests that lymphoma should be considered as a differential diagnosis in bears with a chronic progressive neurological disease.

Keywords

brown bear; Ursus arctos; primary renal large B-cell lymphoma; central nervous system metastases; pathology

Hrčak ID:

170235

URI

https://hrcak.srce.hr/170235

Publication date:

22.11.2016.

Article data in other languages: croatian

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