Veterinarski arhiv, Vol. 86 No. 6, 2016.
Recenzija, Prikaz slučaja
Primary bilateral renal diffuse large B-cell lymphoma with central nervous system metastases in a captive brown bear (Ursus arctos) - a case report.
Ana Beck
orcid.org/0000-0003-4693-3570
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Slaven Reljić
; Department of Biology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Ivan-Conrado Šoštarić-Zuckermann
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Marcin Wrzosek
; Department of Internal Medicine and Clinic of Horses, Dogs and Cats, Faculty of Veterinary Medicine, University of Environmental and Life Sciences, Wroclaw, Poland
Doroteja Huber
; Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Sažetak
We present the first report of primary bilateral renal diffuse large B-cell lymphoma with central nervous system metastases, in a 7 year-old, captive female brown bear. After 7 months of progressive neurological disease, the animal was euthanized. On necropsy, neoplastic nodules with infiltrative growth in the kidneys were found. Neoplastic proliferation of a similar pattern was found compressing the cerebellum and brain stem, and growing through the nervus maxillaris and nervus ophtalmicus. Histology revealed a highly cellular round cell neoplasm, with an infiltrative diffuse growth pattern through the kidneys and nervous parenchyma. On immunohistochemistry, the neoplastic cells stained for the B-cell marker Pax-5. Our report suggests that lymphoma should be considered as a differential diagnosis in bears with a chronic progressive neurological disease.
Ključne riječi
brown bear; Ursus arctos; primary renal large B-cell lymphoma; central nervous system metastases; pathology
Hrčak ID:
170235
URI
Datum izdavanja:
22.11.2016.
Posjeta: 1.836 *