Original scientific paper

https://doi.org/10.20471/acc.2016.55.03.01

Do growth hormone and insulin-like growth factor 1 affect prognosis in patients with killip I and II class acute myocardial infarction?

Larisa Dizdarević-Hudić orcid.org/0000-0001-9221-7052 ; Department of Cardiology, Clinical Department of Internal Medicine,Tuzla University Clinical Center, Tuzla, Bosnia and Herzegovina
Zumreta Kusljugić ; Department of Cardiology, Clinical Department of Internal Medicine,Tuzla University Clinical Center, Tuzla, Bosnia and Herzegovina
Fahir Baraković ; Department of Cardiology, Clinical Department of Internal Medicine,Tuzla University Clinical Center, Tuzla, Bosnia and Herzegovina
Mithad Hajder ; Department of Endocrinology, Clinical Department of Internal Medicine,Tuzla University Clinical Center, Tuzla, Bosnia and Herzegovina
Igor Hudić ; School of Medicine, University of Tuzla, Tuzla, Bosnia and Herzegovina

Abstract

We investigated concentrations and roles of insulin-like growth factor 1 (IGF-1) and its binding protein (IGF1BP-3), growth hormone (GH), insulin, and markers of insulin resistance and inflammation in acute myocardial infarction (AMI). We aimed to assess any possible association between serum GH/IGF-1 axis following AMI and short-term survival rates. A follow up study was performed in 2010. Study group consisted of 75 patients with Killip I and II class AMI. There were 30 control subjects. Blood samples were obtained within 24 hours of admission and analyzed for the aforementioned hormones. Patients were followed-up during 6 months for new cardiac events. Median GH was higher in AMI (0.96; range 0.6-2.4) than in controls (0.26; p<0.001). IGF-1 was significantly lower in AMI (123 vs. 132; p<0.05), and so was the IGF-1/GH ratio (p<0.001) and IGF1BP-3. Insulin was higher in study group, but without statistical significance. However, we found significant between-group differences in other markers of insulin resistance (HbA1c, glycemia, HOMA-IR) and inflammation. Simple linear correlation showed positive correlation between GH and C-reactive protein. All patients with new cardiac events had IGF-1 below median and lower left ventricular ejection fraction. In conclusion, IGF-1 may affect outcome of AMI. GH resistance might be a result of inflammatory/immune response and therefore it could be a useful prognostic marker.

Keywords

Myocardial infarction; Acute disease; Insulin-like growth factor I; Insulin-like growth factor binding protein 3; Growth hormone; Insulin

Hrčak ID:

172383

URI

https://hrcak.srce.hr/172383

Publication date:

9.11.2016.

Article data in other languages: croatian

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