Original scientific paper
Influence of the route of exposure on the acute toxicity of cholinesterase inhibitors
I.L. Natoff
; Shell Research Limited, Tunstall Laboratory, Sittingbourne, Kent, England
Abstract
The acute toxicities of some cholinesterase inhibitor compounds have been determined by the oral, intraperitoneal, subcutaneous, intravenous and intracerebral routes of injection in female mice. The coupounds studied were monocrotophos, dicrotophos, mevinphos, crotoxyphos, dichlorvos, chlorfenvinphos, paraoxon, parathion, neostigmine and eserine. Compounds which are rapidly degraded by the liver are less toxic following oral and intraperitoneal (hepatic routes) injection than they are by subcutaneous and intravenous (peripheral routes) injection. Parathion, which is activated by the liver, tends to be more toxic following administration by the intraperitoneal (hepatic) route. Intracerebral injection by-passes the blood-brain barrier, and the compounds show, with one or two exceptions, a similar order of toxicity by this route of administration compared with the other routes of injection.
Keywords
Hrčak ID:
172840
URI
Publication date:
10.3.1971.
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