Croatica Chemica Acta, Vol. 63 No. 4, 1990.
Original scientific paper
Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. IV. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis
B. Zorc
; Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia, Yugoslavia
G. Karlović
; Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia, Yugoslavia
I. Butula
; Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia, Yugoslavia
Abstract
The use of the 1-benzotriazolylearbonyl-(Bte)-group as an N-protecting and N-activating group in the synthesis of peptides was investigated. Removal of the Btc group from N-Btc-amino acids, their esters and amides under acidic conditions is possible, but has no advantages over removal of benzyloxyearbonyl-(Z)-group.
N-Btc-amino acid esters react with Z-amino acids or Z-dipeptides yielding Z-dipeptide and Z-tripeptide esters, respcetively. This process is aceompanied with separation of benzotriazole and C02. Advantages and disadvantages of this method of peptide bond formation are discussed.
Keywords
Hrčak ID:
176511
URI
Publication date:
26.3.1991.
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