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Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. IV. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis

B. Zorc ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia, Yugoslavia
G. Karlović ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia, Yugoslavia
I. Butula ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia, Yugoslavia

Puni tekst: engleski, pdf (6 MB) str. 565-578 preuzimanja: 72* citiraj
APA 6th Edition
Zorc, B., Karlović, G. i Butula, I. (1990). Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. IV. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis. Croatica Chemica Acta, 63 (4), 565-578. Preuzeto s https://hrcak.srce.hr/176511
MLA 8th Edition
Zorc, B., et al. "Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. IV. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis." Croatica Chemica Acta, vol. 63, br. 4, 1990, str. 565-578. https://hrcak.srce.hr/176511. Citirano 15.11.2019.
Chicago 17th Edition
Zorc, B., G. Karlović i I. Butula. "Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. IV. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis." Croatica Chemica Acta 63, br. 4 (1990): 565-578. https://hrcak.srce.hr/176511
Harvard
Zorc, B., Karlović, G., i Butula, I. (1990). 'Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. IV. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis', Croatica Chemica Acta, 63(4), str. 565-578. Preuzeto s: https://hrcak.srce.hr/176511 (Datum pristupa: 15.11.2019.)
Vancouver
Zorc B, Karlović G, Butula I. Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. IV. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis. Croatica Chemica Acta [Internet]. 1990 [pristupljeno 15.11.2019.];63(4):565-578. Dostupno na: https://hrcak.srce.hr/176511
IEEE
B. Zorc, G. Karlović i I. Butula, "Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. IV. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis", Croatica Chemica Acta, vol.63, br. 4, str. 565-578, 1990. [Online]. Dostupno na: https://hrcak.srce.hr/176511. [Citirano: 15.11.2019.]

Sažetak
The use of the 1-benzotriazolylearbonyl-(Bte)-group as an N-protecting and N-activating group in the synthesis of peptides was investigated. Removal of the Btc group from N-Btc-amino acids, their esters and amides under acidic conditions is possible, but has no advantages over removal of benzyloxyearbonyl-(Z)-group.
N-Btc-amino acid esters react with Z-amino acids or Z-dipeptides yielding Z-dipeptide and Z-tripeptide esters, respcetively. This process is aceompanied with separation of benzotriazole and C02. Advantages and disadvantages of this method of peptide bond formation are discussed.

Hrčak ID: 176511

URI
https://hrcak.srce.hr/176511

Posjeta: 124 *