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Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske, Vol. 70 No. Suplement 2, 2016.

Review article

NON-MELANOMA SKIN CANCER IN RENAL TRANSPLANT RECIPIENTS: DO WE STILL OVERLOOK IT?

ZRINKA BUKVIĆ MOKOS ; Zagreb University Hospital Center, School of Medicine, University of Zagreb, Clinical Department of Dermatology and Venereology, Zagreb, Croatia
TAJANA BORLINIĆ ; Čakovec General Hospital, Dermatovenereology Unit, Čakovec,Croatia
NIKOLINA BAŠIĆ-JUKIĆ ; Zagreb University Hospital Center, School of Medicine, University of Zagreb, Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Zagreb, Croatia
PETAR KES ; Zagreb University Hospital Center, School of Medicine, University of Zagreb, Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, Zagreb, Croatia
IVICA MOKOS ; Zagreb University Hospital Center, Department of Urology, Zagreb, Croatia

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Abstract

Non-melanoma skin cancer (NMSC) is the most frequent cancer in renal transplant recipients (RTRs). Clinical and epidemiological studies indicate that long-life immunosuppressive therapy that is essential for preventing graft rejection and obtaining adequate graft function after renal transplantation, combined with older age at transplantation, total sun burden during life, fair skin type and personal history of treated NMSC before transplantation, are the most important risk factors for NMSC development. Since RTRs are more susceptible to developing more aggressive types of skin cancers, especially squamous cell carcinoma (SCC), it is of great importance to develop cancer awareness in these patients, making them sensitive to sun protection and regular dermatologic and skin self-examination. Immunosuppressive therapy as a risk factor of high importance has to be individually tailored and, if necessary, altered in order to decrease cancer formation as much as possible, while preserving graft survival and function. Therefore, interdisciplinary approach, including primarily nephrologists and dermatologists, should be employed in follow up of RTRs, thus enabling prevention, early diagnosing and appropriate treatment of NMSC in these patients.

Keywords

renal transplantation; immunosuppression; skin cancer; epidemiologic studies

Hrčak ID:

180157

URI

https://hrcak.srce.hr/180157

Publication date:

6.4.2017.

Article data in other languages: croatian

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