Pregledni rad
NON-MELANOMA SKIN CANCER IN RENAL TRANSPLANT RECIPIENTS: DO WE STILL OVERLOOK IT?
ZRINKA BUKVIĆ MOKOS
; Klinički bolnički centar Zagreb, Sveučilište u Zagrebu, Medicinski fakultet, Klinika za dermatologiju i venerologiju, Zagreb, Hrvatska
TAJANA BORLINIĆ
; Opća bolnica Čakovec, Odjel za dermatovenerologiju, Čakovec, Hrvatska
NIKOLINA BAŠIĆ-JUKIĆ
; Klinički bolnički centar Zagreb, Sveučilište u Zagrebu, Medicinski fakultet, Klinika za nefrologiju, arterijsku hipertenziju, dijalizu i transplantaciju, Zagreb, Hrvatska
PETAR KES
; Klinički bolnički centar Zagreb, Sveučilište u Zagrebu, Medicinski fakultet, Klinika za nefrologiju, arterijsku hipertenziju, dijalizu i transplantaciju, Zagreb, Hrvatska
IVICA MOKOS
; Klinički bolnički centar Zagreb, Klinika za urologiju, Zagreb, Hrvatska
Sažetak
Non-melanoma skin cancer (NMSC) is the most frequent cancer in renal transplant recipients (RTRs). Clinical and epidemiological studies indicate that long-life immunosuppressive therapy that is essential for preventing graft rejection and obtaining adequate graft function after renal transplantation, combined with older age at transplantation, total sun burden during life, fair skin type and personal history of treated NMSC before transplantation, are the most important risk factors for NMSC development. Since RTRs are more susceptible to developing more aggressive types of skin cancers, especially squamous cell carcinoma (SCC), it is of great importance to develop cancer awareness in these patients, making them sensitive to sun protection and regular dermatologic and skin self-examination. Immunosuppressive therapy as a risk factor of high importance has to be individually tailored and, if necessary, altered in order to decrease cancer formation as much as possible, while preserving graft survival and function. Therefore, interdisciplinary approach, including primarily nephrologists and dermatologists, should be employed in follow up of RTRs, thus enabling prevention, early diagnosing and appropriate treatment of NMSC in these patients.
Ključne riječi
renal transplantation; immunosuppression; skin cancer; epidemiologic studies
Hrčak ID:
180157
URI
Datum izdavanja:
6.4.2017.
Posjeta: 1.475 *