Periodicum biologorum, Vol. 120 No. 1, 2018.
Review article
https://doi.org/10.18054/pb.v120i1.6229
A young researcher’s guide to NME/Nm23/NDP Kinase
Maja Herak Bosnar
orcid.org/0000-0002-8448-4713
; Ruđer Bošković Institute
Martina Radić
; Ruđer Bošković Institute
Helena Ćetković
; Ruđer Bošković Institute
Abstract
Nucleoside diphosphate kinases (NDPKs) catalyze the exchange of the terminal phosphate from trinucleotides to dinucleotides through a high-energy phosphohistidine intermedier. They are encoded by NME genes and have been found, with a few exceptions, in all living beings. Besides their well-known function as key regulators of the cellular nucleotide homeostasis, they have been appointed numerous additional biochemical and biological functions. The discovery of NME1/NDPK A as the first metastasis suppressor opened new avenues in cancer research. Although the precise role of NME genes/proteins in cancer dissemination is not yet revealed, it seems that further intensive research in this field may lead to new advances in cancer diagnosis and prognosis, as well as encourage new therapeutic strategies.
Keywords
Hrčak ID:
204224
URI
Publication date:
30.6.2018.
Visits: 2.181 *