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Croatian Journal of Infection, Vol. 37 No. 1, 2017.

Other

The use of a single-pass albumin dialysis (SPAD) to correct severe hyperbilirubinemia in Weil's disease: a case report

Viktor Kotarski ; University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Zagreb, Croatia
Marija Santini ; University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Zagreb, Croatia
Marko Kutleša ; University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Zagreb, Croatia
Renata Josipović ; University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Zagreb, Croatia
Anđa Novokmet ; University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Zagreb, Croatia
Tomislav Krčelić ; University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Zagreb, Croatia
Vladimir Krajinović ; University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Zagreb, Croatia
Bruno Baršić ; University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Zagreb, Croatia

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Abstract

Liver failure, regardless of the cause, carries a high risk of morbidity and mortality. Many of the toxins that accumulate in liver failure are poorly water-soluble and are thus transported through the bloodstream bound to albumins. Renal replacement therapy does not significantly alter the concentration of bilirubin and other albumin-bound toxins in the serum. In patients with liver failure additional detoxification methods are needed. There are several artificial extracorporeal liver support systems based on the principle of albumin but their availability is limited due to high cost and requirement of operators with special training. There have been several reports of using SPAD (single pass albumin dialysis) as an effective alternative. The main advantage of this method is that it
can be performed using conventional renal replacement therapy (RRT) devices. In this report, the authors report the use of SPAD to treat severe liver failure in a patient with Weil's disease.

Keywords

leptospirosis; hyperbilirubinemia; single-pass albumin dialysis

Hrčak ID:

216062

URI

https://hrcak.srce.hr/216062

Publication date:

22.1.2019.

Article data in other languages: croatian

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