Original scientific paper

TNF-alpha, CXCL8, big ET-1 and hsCRP in Patients with Chronic Obstructive Pulmonary Disease

Sanja Marević orcid.org/0000-0003-4465-1457 ; Dr Fran Mihaljević University Hospital for Infectious Diseases, Zagreb, Croatia
József Petrik ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Nada Vrkić ; Sestre milosrdnice University Hospital, Zagreb, Croatia
Sanja Popović-Grle ; Jordanovac University Hospital for Lung Diseases, Zagreb, Croatia
Tihana Žanić-Grubišić ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Ivana Čepelak ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia

Abstract

COPD (chronic obstructive pulmonary disease) is a chronic progressive inflammatory disease characterised by limitations in lung airflow that is not fully reversible. The concentrations and correlations of TNF-á, CXCL8, big ET-1 and hsCRP were investigated in healthy non-smokers, healthy smokers and patients with COPD in order to study their possible role in the pathophysiology of COPD. The concentrations of TNF-á, CXCL8 and big ET-1 were not statistically different between the experimental groups. No significant differences for the measured analytes were found between smokers and the non-smokers in the control group. The Spearman coefficient of correlation between the concentrations of TNF-á and CXCL8 was r = 0.638 (p<0.0001). However, the concentration of hsCRP was significantly higher in patients with COPD than in the control group (p = 0.0004). hsCRP proved to be a more sensitive diagnostic parameter than TNF-á, CXCL8 and big ET-1 in the systemic circulation in patients with COPD.

Keywords

COPD; TNF-alpha; CXCL8; big ET-1; hsCRP

Hrčak ID:

23450

URI

https://hrcak.srce.hr/23450

Publication date:

15.4.2008.

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