Original scientific paper
Anti-Inflammatory Effects of Exercise Training in the Early Period after Myocardial Infarction
Sanja Balen
Nada Vukelić-Damijani
Viktor Peršić
Alen Ružić
Bojan Miletić
Marina Samardžija
Dragoslav Domanović
Jure Mirat
Dario Naki
Ivan Soldo
Aleksandar Včev
Abstract
The aim of this investigation was to determine the effect of exercise training on the levels of plasma cytokines and
acute phase reactants in the early post acute myocardial infarction (AMI) period. Sixty patients were enrolled into this
three-week cardiac rehabilitation study. The mean time from AMI was 7.081.60 days, and the patient mean age was
6010 years. Subjects were randomly assigned to one of the two groups: the control group treated with standard measures,
and the group with additional regular moderate-intensity exercise training. Physical activity was based on the
ergospirometry test results. Apart from clinical follow-up and routine laboratory analysis we determined the levels of
plasma cytokines: tumor necrosis factor (TNF-), soluble TNF- receptor 1(TNF-SR1), interleukin (IL)-8, IL-10, and
acute phase reactants: high sensitivity C-reactive protein (hsCRP) and fibrinogen. The obtained results confirmed the hypothesis
that the early post AMI period is an inflammatory state the intensity of which gradually decreases with standard
treatment during the first month after AMI, while including patients into early exercise training improves their inflammatory
profile by decreasing the level of acute phase reactant and TNF-SR1.
Keywords
early cardiac rehabilitation; cytokine; acute phase reactants
Hrčak ID:
23744
URI
Publication date:
8.5.2008.
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