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Anti-Inflammatory Effects of Exercise Training in the Early Period after Myocardial Infarction

Sanja Balen
Nada Vukelić-Damijani
Viktor Peršić
Alen Ružić
Bojan Miletić
Marina Samardžija
Dragoslav Domanović
Jure Mirat
Dario Naki
Ivan Soldo
Aleksandar Včev


Puni tekst: engleski pdf 82 Kb

str. 285-291

preuzimanja: 629

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Sažetak

The aim of this investigation was to determine the effect of exercise training on the levels of plasma cytokines and
acute phase reactants in the early post acute myocardial infarction (AMI) period. Sixty patients were enrolled into this
three-week cardiac rehabilitation study. The mean time from AMI was 7.081.60 days, and the patient mean age was
6010 years. Subjects were randomly assigned to one of the two groups: the control group treated with standard measures,
and the group with additional regular moderate-intensity exercise training. Physical activity was based on the
ergospirometry test results. Apart from clinical follow-up and routine laboratory analysis we determined the levels of
plasma cytokines: tumor necrosis factor (TNF-), soluble TNF- receptor 1(TNF-SR1), interleukin (IL)-8, IL-10, and
acute phase reactants: high sensitivity C-reactive protein (hsCRP) and fibrinogen. The obtained results confirmed the hypothesis
that the early post AMI period is an inflammatory state the intensity of which gradually decreases with standard
treatment during the first month after AMI, while including patients into early exercise training improves their inflammatory
profile by decreasing the level of acute phase reactant and TNF-SR1.

Ključne riječi

early cardiac rehabilitation, cytokine, acute phase reactants

Hrčak ID:

23744

URI

https://hrcak.srce.hr/23744

Posjeta: 1.084 *