Original scientific paper
https://doi.org/10.2478/10004-1254-59-2008-1853
Lipid Peroxidation and Antioxidative Enzyme Activity in Erythrocytes of Workers Occupationally Exposed to Aluminium
Petar Bulat
orcid.org/0000-0002-4311-8960
; Institute of Occupational Health “Dr Dragomir Karajović”, Beograd, Serbia
Biljana Potkonjak
; Institute of Immunology “Torlak”, Beograd, Serbia
Ivana Đujić
; Institute of Chemistry, Technology and Metallurgy, Beograd, Serbia
Abstract
Current research indicates that lipid peroxidation could have a role in aluminium toxicity. The aim of this study was to asses lipid peroxidation and antioxidative enzyme activity in erythrocytes of workers occupationally exposed to aluminium. We investigated a group of 59 workers (Al group) exposed to aluminium fumes (contamination factor F=8.07 to 13.47, national maximal allowed concentration value is 2 mg m-3). The control group (C group) consisted of 75 subjects employed in lime production who had not been occupationally exposed to aluminium or any known toxic substance. Erythrocyte aluminium concentrations were significantly higher in the exposed group than controls [Al group (8.41±3.66) µg L-1, C group (5.60±0.86) µg L-1, p<0.001]. In the Al group, erythrocyte malondialdehyde concentration was also significantly higher [Al group (189.59±81.27) µmol L-1, C group (105.21±49.62) µmol L-1, p<0.001] and antioxidative enzyme activity reduced for glucoso-6-phosphatedehydrogenase [Al group (5.05±1.70) IU g-1 Hb, C group (12.53±4.12) IU g-1 Hb, p<0.001], glutathione reductase [Al group (1.41±0.56) IU g-1 Hb, C group (1.89±0.57) IU g-1 Hb, p<0.001], glutathione peroxidase [Al group (12.37±5.76) IU g-1 Hb, C group (15.54±4.85) IU g-1 Hb, p<0.001], catalase [Al group (116.76±26.60) IU g-1 Hb, C group (158.81±71.85) IU g-1 Hb, p<0.001] and superoxide dismutase [Al group (1175.8±149.9) IU mg-1 Hb, C group (1377.9±207.5) IU mg-1 Hb, p<0.001].
Keywords
catalase; glucoso-6-phosphate-dehydrogenase; glutathione peroxidase; glutathione reductase; malondialdehyde; occupational exposure; superoxide dismutase
Hrčak ID:
24805
URI
Publication date:
23.6.2008.
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