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Lipid Peroxidation and Antioxidative Enzyme Activity in Erythrocytes of Workers Occupationally Exposed to Aluminium

Petar Bulat orcid id ; Institute of Occupational Health “Dr Dragomir Karajović”, Beograd, Serbia
Biljana Potkonjak ; Institute of Immunology “Torlak”, Beograd, Serbia
Ivana Đujić ; Institute of Chemistry, Technology and Metallurgy, Beograd, Serbia

Puni tekst: engleski pdf 78 Kb

str. 81-87

preuzimanja: 1.003



Current research indicates that lipid peroxidation could have a role in aluminium toxicity. The aim of this study was to asses lipid peroxidation and antioxidative enzyme activity in erythrocytes of workers occupationally exposed to aluminium. We investigated a group of 59 workers (Al group) exposed to aluminium fumes (contamination factor F=8.07 to 13.47, national maximal allowed concentration value is 2 mg m-3). The control group (C group) consisted of 75 subjects employed in lime production who had not been occupationally exposed to aluminium or any known toxic substance. Erythrocyte aluminium concentrations were significantly higher in the exposed group than controls [Al group (8.41±3.66) µg L-1, C group (5.60±0.86) µg L-1, p<0.001]. In the Al group, erythrocyte malondialdehyde concentration was also significantly higher [Al group (189.59±81.27) µmol L-1, C group (105.21±49.62) µmol L-1, p<0.001] and antioxidative enzyme activity reduced for glucoso-6-phosphatedehydrogenase [Al group (5.05±1.70) IU g-1 Hb, C group (12.53±4.12) IU g-1 Hb, p<0.001], glutathione reductase [Al group (1.41±0.56) IU g-1 Hb, C group (1.89±0.57) IU g-1 Hb, p<0.001], glutathione peroxidase [Al group (12.37±5.76) IU g-1 Hb, C group (15.54±4.85) IU g-1 Hb, p<0.001], catalase [Al group (116.76±26.60) IU g-1 Hb, C group (158.81±71.85) IU g-1 Hb, p<0.001] and superoxide dismutase [Al group (1175.8±149.9) IU mg-1 Hb, C group (1377.9±207.5) IU mg-1 Hb, p<0.001].

Ključne riječi

catalase, glucoso-6-phosphate-dehydrogenase, glutathione peroxidase, glutathione reductase, malondialdehyde, occupational exposure, superoxide dismutase

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Podaci na drugim jezicima: hrvatski

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