Review article
Pathophysiological reasons for the failure of the cerebral perivascular drainage and progression of Alzheimer’s disease
Nikola Barić
Full text: english pdf 522 Kb
page 42-54
downloads: 348
cite
APA 6th Edition
Barić, N. (2020). Pathophysiological reasons for the failure of the cerebral perivascular drainage and progression of Alzheimer’s disease. Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, . (544 =52-53), 42-54. Retrieved from https://hrcak.srce.hr/248881
MLA 8th Edition
Barić, Nikola. "Pathophysiological reasons for the failure of the cerebral perivascular drainage and progression of Alzheimer’s disease." Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, vol. ., no. 544 =52-53, 2020, pp. 42-54. https://hrcak.srce.hr/248881. Accessed 19 Nov. 2024.
Chicago 17th Edition
Barić, Nikola. "Pathophysiological reasons for the failure of the cerebral perivascular drainage and progression of Alzheimer’s disease." Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti ., no. 544 =52-53 (2020): 42-54. https://hrcak.srce.hr/248881
Harvard
Barić, N. (2020). 'Pathophysiological reasons for the failure of the cerebral perivascular drainage and progression of Alzheimer’s disease', Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, .(544 =52-53), pp. 42-54. Available at: https://hrcak.srce.hr/248881 (Accessed 19 November 2024)
Vancouver
Barić N. Pathophysiological reasons for the failure of the cerebral perivascular drainage and progression of Alzheimer’s disease. Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti [Internet]. 2020 [cited 2024 November 19];.(544 =52-53):42-54. Available from: https://hrcak.srce.hr/248881
IEEE
N. Barić, "Pathophysiological reasons for the failure of the cerebral perivascular drainage and progression of Alzheimer’s disease", Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, vol.., no. 544 =52-53, pp. 42-54, 2020. [Online]. Available: https://hrcak.srce.hr/248881. [Accessed: 19 November 2024]
Full text: croatian pdf 522 Kb
page 42-54
downloads: 243
cite
APA 6th Edition
Barić, N. (2020). Pathophysiological reasons for the failure of the cerebral perivascular drainage and progression of Alzheimer’s disease. Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, . (544 =52-53), 42-54. Retrieved from https://hrcak.srce.hr/248881
MLA 8th Edition
Barić, Nikola. "Pathophysiological reasons for the failure of the cerebral perivascular drainage and progression of Alzheimer’s disease." Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, vol. ., no. 544 =52-53, 2020, pp. 42-54. https://hrcak.srce.hr/248881. Accessed 19 Nov. 2024.
Chicago 17th Edition
Barić, Nikola. "Pathophysiological reasons for the failure of the cerebral perivascular drainage and progression of Alzheimer’s disease." Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti ., no. 544 =52-53 (2020): 42-54. https://hrcak.srce.hr/248881
Harvard
Barić, N. (2020). 'Pathophysiological reasons for the failure of the cerebral perivascular drainage and progression of Alzheimer’s disease', Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, .(544 =52-53), pp. 42-54. Available at: https://hrcak.srce.hr/248881 (Accessed 19 November 2024)
Vancouver
Barić N. Pathophysiological reasons for the failure of the cerebral perivascular drainage and progression of Alzheimer’s disease. Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti [Internet]. 2020 [cited 2024 November 19];.(544 =52-53):42-54. Available from: https://hrcak.srce.hr/248881
IEEE
N. Barić, "Pathophysiological reasons for the failure of the cerebral perivascular drainage and progression of Alzheimer’s disease", Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, vol.., no. 544 =52-53, pp. 42-54, 2020. [Online]. Available: https://hrcak.srce.hr/248881. [Accessed: 19 November 2024]
Abstract
The disorder of intracerebral perivascular drainage of amyloid beta (Aβ), as well as the drainage of various waste products related to a number of permanent biochemical reactions and physiological processes, leads to brain homeostasis disorders, breakdown of essential vital functions and rapid course of genetically programmed Alzheimer’s disease. As the brain does not have its own standard glymphatic system, this important function is mostly taken over by the perivascular system located within the basement membranes of capillaries, arterioles and arteries. The crucial driving force of this drainage, according to recent investigations, is conditioned by the internal force of arterial and arteriolar walls, the so-called vasomotion. With the direction opposite from the direction of the blood stream and pulse wave, this pulsating force is based on rhythmic intracellular oscillations of Ca2+ ion concentration in vascular smooth muscle cells. These oscilations are the fundament of the vasomotion phenomenon, and their disorder leads to perivascular drainage alterations and severe complications. The aim of this review is to present a detailed analysis of crucial events that are important for perivascular drainage system alterations.
Keywords
Alzheimer’s disease, perivascular drainage alterations, glymphatic system, vasomotion phenomenon
Hrčak ID:
248881
URI
https://hrcak.srce.hr/248881
Publication date:
15.12.2020.
Article data in other languages:
croatian
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