Original scientific paper

https://doi.org/10.20471/acc.2020.59.04.16

The Association of Subclinical Insulin Resistance with Thyroid Autoimmunity in Euthyroid Individuals

Kristina Blaslov ; Mladen Sekso Department of Endocrinology, Diabetes and Metabolic Diseases, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Domagoj Gajski ; Department of Neurosurgery, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; School of Dental Medicine, University of Zagreb, Zagreb, Croatia; University of Applied Health Sciences, Zagreb, Croatia
Vesna Vucelić ; Mladen Sekso Department of Endocrinology, Diabetes and Metabolic Diseases, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Petar Gaćina ; Department of Internal Medicine, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia
Gorana Mirošević ; Mladen Sekso Department of Endocrinology, Diabetes and Metabolic Diseases, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Jelena Marinković ; Mladen Sekso Department of Endocrinology, Diabetes and Metabolic Diseases, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia
Milan Vrkljan ; Mladen Sekso Department of Endocrinology, Diabetes and Metabolic Diseases, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia
Krešimir Rotim ; Department of Neurosurgery, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; University of Applied Health Sciences, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia

Abstract

Hashimoto thyroiditis is characterized by anti-thyroid peroxidase (anti-TPO) and
anti-thyroglobulin (anti-Tg) antibodies that gradually lead to thyroid cell destruction. As hypothyroidism
has been associated with insulin resistance (IR), we aimed to investigate whether IR is associated
with thyroid antibody presence and whether the degree of IR correlates with their concentration
in euthyroid individuals. A total of 164 non-diabetic, euthyroid individuals, average age 34 years, were
included in the study, divided into two groups according to Hashimoto thyroiditis and underwent
5-hour oral glucose tolerance test. The degree of IR was evaluated by the Homeostatic Model Assessment
of Insulin Resistance (HOMA-IR). The Hashimoto thyroiditis group had higher HOMA-IR
(p=0.003) and lower glucose levels (p=0.04). HOMA-IR correlated positively with anti-TPO
(p<0.001). Linear logistic regression revealed that anti-TPO concentration increased by 18.13
(p=0.001) with each HOMA-IR unit. IR might trigger thyroid antibody production and Hashimoto
thyroiditis development, which needs to be evaluated in further larger scale follow up studies.

Keywords

Insulin resistance; 5-hour oral glucose tolerance test; Hashimoto thyroiditis

Hrčak ID:

254883

URI

https://hrcak.srce.hr/254883

Publication date:

1.12.2020.

Article data in other languages: croatian

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