Review article
https://doi.org/10.21860/medflum2021_371640
Tip of the iceberg: Immunohistochemical markers reveal malignant transformation underneath a vocal polyp surface
Tamara Braut
; University of Rijeka, Faculty of Medicine, Department of Otorhinolaryngology, Rijeka, Croatia
Mira Krstulja
; University of Rijeka, Faculty of Medicine, Department of General Pathology and Pathological Anatomy, Rijeka, Croatia
Blažen Marijić
; University of Rijeka, Faculty of Medicine, Department of Otorhinolaryngology, Rijeka, Croatia
Diana Maržić
; University of Rijeka, Faculty of Medicine, Department of Otorhinolaryngology, Rijeka, Croatia
Milodar Kujundžić
; University of Rijeka, Faculty of Medicine, Department of Otorhinolaryngology, Rijeka, Croatia
Gordana Zamolo
; University of Rijeka, Faculty of Medicine, Department of General Pathology and Pathological Anatomy, Rijeka, Croatia
Damir Vučinić
; Clinic for Radiotherapy and Oncology, Clinical Hospital Centre of Rijeka, Rijeka, Croatia
Eduard Oštarijaš
orcid.org/0000-0001-9999-9886
; Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary
Abstract
Abstract. Novel molecular techniques including markers of laryngeal carcinogenesis could improve the difficult diagnosis of a wide array of laryngeal polypoid changes. The case reported herein shows that not every clinically diagnosed vocal fold polyp is a benign lesion as mostly considered in the literature. Further assessment including carcinogenesis markers detected a nest of micro-invasive squamous cell carcinoma. Therefore, we recommend biopsy backed up with immunohistochemical analysis whenever there is a suspicious polypoid formation in order to exclude or confirm a malignant transformation because of the possibility of multi-focal growth in the active laryngeal epithelium.
Keywords
epithelial atypia; immunohistochemistry; laryngeal polyps; molecular markers; squamous cell carcinoma
Hrčak ID:
255655
URI
Publication date:
1.6.2021.
Visits: 1.012 *