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Pregledni rad

https://doi.org/10.21860/medflum2021_371640

Tip of the iceberg: Immunohistochemical markers reveal malignant transformation underneath a vocal polyp surface

Tamara Braut ; University of Rijeka, Faculty of Medicine, Department of Otorhinolaryngology, Rijeka, Croatia
Mira Krstulja ; University of Rijeka, Faculty of Medicine, Department of General Pathology and Pathological Anatomy, Rijeka, Croatia
Blažen Marijić ; University of Rijeka, Faculty of Medicine, Department of Otorhinolaryngology, Rijeka, Croatia
Diana Maržić ; University of Rijeka, Faculty of Medicine, Department of Otorhinolaryngology, Rijeka, Croatia
Milodar Kujundžić ; University of Rijeka, Faculty of Medicine, Department of Otorhinolaryngology, Rijeka, Croatia
Gordana Zamolo ; University of Rijeka, Faculty of Medicine, Department of General Pathology and Pathological Anatomy, Rijeka, Croatia
Damir Vučinić ; Clinic for Radiotherapy and Oncology, Clinical Hospital Centre of Rijeka, Rijeka, Croatia
Eduard Oštarijaš orcid id orcid.org/0000-0001-9999-9886 ; Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary


Puni tekst: engleski pdf 2.734 Kb

str. 171-176

preuzimanja: 190

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Sažetak

Abstract. Novel molecular techniques including markers of laryngeal carcinogenesis could improve the difficult diagnosis of a wide array of laryngeal polypoid changes. The case reported herein shows that not every clinically diagnosed vocal fold polyp is a benign lesion as mostly considered in the literature. Further assessment including carcinogenesis markers detected a nest of micro-invasive squamous cell carcinoma. Therefore, we recommend biopsy backed up with immunohistochemical analysis whenever there is a suspicious polypoid formation in order to exclude or confirm a malignant transformation because of the possibility of multi-focal growth in the active laryngeal epithelium.

Ključne riječi

epithelial atypia, immunohistochemistry, laryngeal polyps, molecular markers, squamous cell carcinoma

Hrčak ID:

255655

URI

https://hrcak.srce.hr/255655

Podaci na drugim jezicima: hrvatski

Posjeta: 506 *