Original scientific paper
https://doi.org/10.20471/acc.2021.60.s1.20
Clinical Significance of Zero-Time Renal Transplant Biopsies and Thin Glomerular Basement Membranes in Zero-Time Renal Transplant Biopsies
Petar Šenjug
; Department of Nephropathology and Electron Microscopy, Department of Pathology and Cytology, Dubrava University Hospital, Zagreb, Croatia
Matija Horaček
; Institute of Pathology, School of Medicine, University of Zagreb, Zagreb, Croatia
Bojana Maksimović
; Department of Nephrology, Merkur University Hospital, Zagreb, Croatia
Ksenija Vučur
; Department of Nephrology, Merkur University Hospital, Zagreb, Croatia
Ivica Horvatić
; Department of Nephrology, Dubrava University Hospital, Zagreb, Croatia
Nikola Zagorec
; Department of Nephrology, Dubrava University Hospital, Zagreb, Croatia
Mladen Knotek
; Renal Division, University Hospital Crosshouse, Kilmarnock, United Kingdom
Danica Galešić Ljubanović
; Department of Nephropathology and Electron Microscopy, Department of Pathology and Cytology, Dubrava University Hospital, Zagreb, Croatia; Institute of Pathology, School of Medicine, University of Zagreb, Zagreb, Croatia
Abstract
Aim. To investigate morphological findings of zero-time biopsies analyzed at the
Department of Nephropathology and Electron Microscopy, Dubrava University Hospital, Zagreb.
Materials and methods. The retrospective search of data was performed for the period from 2006 to
2018. A total of 316 zero-time renal biopsies were analyzed. Glomerular basement membrane (GBM)
thickness was remeasured in 84 zero-time biopsies and 80 protocol biopsies of the same patients 12
months after transplantation.
Results and conclusion. The acute tubular injury was present in 90% and glomerular pathology in
17% of zero-time biopsies, with thin basement membranes (TBM ) being the most common entity
(13%). Chronic graft changes were evaluated according to Banff classification. Most cases showed
Banff scores ci0 (82.6%) and ct0 (65.1%). Banff scores cv2 and cv3 were present in 13% and ah2 and
ah3 in 36.4% of specimens. Among 84 remeasured zero-time samples, TBM was present in 26 patients
(31%). There were no differences between Banff scores and clinical parameters 12 months after
transplantation between recipients with TBM and recipients with normal GBM thickness.
Zero-time renal biopsy is of great importance for allograft assessment and comparison with consecutive
biopsies. Further investigation is needed to determine the long-term significance of TBM on
graft survival.
Keywords
Zero-time renal biopsies; Glomerular basement membrane; Thin basement membrane
Hrčak ID:
260432
URI
Publication date:
1.1.2021.
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