Original scientific paper
https://doi.org/10.20471/acc.2021.60.s1.23
Clinical Characteristics and Treatment of Lupus Nephritis – Preliminary Analysis of Observational Data From a National Referral Centre
Tamara Knežević
; Division of Nephrology, Hypertension, Dialysis and Transplantation, University Hospital Centre Zagreb, National Referral Centre for Glomerular and Tubulointerstitial Diseases, Zagreb, Croatia
Ivan Padjen
; Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, University Hospital Centre Zagreb and University of Zagreb School of Medicine, National Referral Centre for Systemic Lupus Erythematosus and Related Diseases, Zagreb, Croatia; University of Zagreb, School of Medicine, Zagreb, Croatia
Stela Bulimbašić
; Department of Pathology and Cytology, University Hospital Centre Zagreb, Croatia; University of Zagreb, School of Medicine, Zagreb, Croatia
Marijana Ćorić
; Department of Pathology and Cytology, University Hospital Centre Zagreb, Croatia; University of Zagreb, School of Medicine, Zagreb, Croatia
Vanja Ivković
; Division of Nephrology, Hypertension, Dialysis and Transplantation, University Hospital Centre Zagreb, National Referral Centre for Glomerular and Tubulointerstitial Diseases, Zagreb, Croatia; University of Rijeka, Faculty of Health Studies, Rijeka, Croatia
Mario Laganović
; Division of Nephrology, Hypertension, Dialysis and Transplantation, University Hospital Centre Zagreb, National Referral Centre for Glomerular and Tubulointerstitial Diseases, Zagreb, Croatia; University of Zagreb, School of Medicine, Zagreb, Croatia
Branimir Anić
; Division of Clinical Immunology and Rheumatology, Department of Internal Medicine, University Hospital Centre Zagreb and University of Zagreb School of Medicine, National Referral Centre for Systemic Lupus Erythematosus and Related Diseases, Zagreb, Croatia; University of Zagreb, School of Medicine, Zagreb, Croatia
Abstract
Lupus nephritis (LN) is one of the most severe features of systemic lupus erythematosus
(SLE). Data on LN is scarce in the Croatian population. We analysed the characteristics of
LN patients diagnosed at our tertiary referral centre. In this retrospective study, we analysed the following
features of patients with biopsy-proven LN diagnosed between 2011 and 2020: demographics,
renal laboratory parameters, renal histopathology, and treatment.
A total of 38 patients were included (30 females; mean age 39±15 years). The most common indication
for kidney biopsy was proteinuria (89%). The proportion of LN classes was: class I (2.6%), II
(5.3%), III (18.4%), IV (42.1%), V (13.2%), III+V (10.5%), IV+V (5.3%). The median time from SLE
diagnosis to histologic confirmation of LN was 1.0 year. All patients were treated with methylprednisolone
(MP), 68% received MP pulses. Induction treatment included intravenous (IV) cyclophosphamide
(CYC) (71%) (15 patients treated per Euro-Lupus and 9 per the National Institutes of
Health regimen), oral CYC (3%), or mycophenolate mofetil (11%). 79% of patients received antimalarials.
While there is heterogeneity between different populations, our patient profile was similar to
that from other European studies. Further follow-up of this group is necessary to assess outcomes in
our population.
Keywords
systemic lupus erythematosus; Lupus nephritis; Treatment; Population characteristics
Hrčak ID:
260439
URI
Publication date:
1.1.2021.
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