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Acta clinica Croatica, Vol. 60. No. Supplement 1, 2021.

Original scientific paper

https://doi.org/10.20471/acc.2021.60.s1.24

Sex Differences in Cardiovascular Risk Factors and Renal Function among Young Adults after Intrauterine Growth Restriction

Lorka Tarnovski ; School of Medicine, University of Zagreb, Zagreb
Ivana Vuković Brinar ; University Hospital Center Zagreb; School of Medicine, University of Zagreb, Zagreb
Majda Vrkić Kirhmajer ; University Hospital Center Zagreb; School of Medicine, University of Zagreb, Zagreb
Tajana Željković Vrkić ; University Hospital Center Zagreb; School of Medicine, University of Zagreb, Zagreb
Mario Laganović orcid id orcid.org/0000-0002-0240-4178 ; University Hospital Center Zagreb; School of Medicine, University of Zagreb, Zagreb

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Abstract

Introduction: Intrauterine growth restriction (IUGR) is linked to a higher incidence
of cardiovascular and renal diseases.
Methods: A total of 91 healthy individuals were included, 40 women and 51 men, born below the
10th percentile of birth weight for gestational age. Anthropometric parameters, arterial pressure (AP),
blood glucose, estimated glomerular filtration rate (eGFR), albumin/creatinine ratio, lipid profile, uric
acid, renal volume by ultrasound, pulse wave velocity, central arterial pressure (cAP), and augmentation
index (Aix) were measured.
Results: Men have higher body mass index (BMI), waist circumference, ambulatory and continuous
AP, lower eGFR, pulse, higher uric acid and LDL cholesterol, lower HDL cholesterol, higher cAP
and Aix, higher corrected renal volume, and birth weight than females. Overweight men had hypertension,
lower eGFR, and dyslipidemia more often. Systolic pressure correlated positively with BMI
in men. In women, systolic pressure correlated positively with heart rate and negatively with gestational
age. BMI affected the systolic pressure in men and eGFR in women.
Conclusion: Results indicate the more unfavourable effect of IUGR on men. Higher AP, vascular
dysfunction, poorer renal function, and dyslipidemia predispose men to earlier chronic disease development.

Keywords

Intrauterine growth restriction; Arterial pressure; Renal function

Hrčak ID:

260444

URI

https://hrcak.srce.hr/260444

Publication date:

1.1.2021.

Article data in other languages: croatian

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