Original scientific paper

NUCLEOTIDE SUPPLEMENTATION ELIMINATES LEUKOCYTE DNA DAMAGE INDUCED BY T-2 TOXIN AND DEOXYNIVALENOL IN BROILER CHICKENS

Tamara Frankič ; Institute of Nutrition, Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, 1230 Domžale, Slovenia
Vida Rezar ; Institute of Nutrition, Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, 1230 Domžale, Slovenia
Janez Salobir ; Institute of Nutrition, Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, 1230 Domžale, Slovenia

Abstract

This study shows that Fusarium mycotoxins, T-2 toxin and DON impair the performance of broiler chickens, induce DNA damage in chicken leukocytes and cause oxidative stress in the organism. When
considering feed consumption and live weight gain in mycotoxicosis induced with high levels of T-2 toxin and DON present in the feed, dietary nucleotides do not have beneficial effect. The crucial role of
nucleotide supplementation in feed is to repair DNA damage in immune cells, which are highly sensitive to mycotoxin action. When broilers are exposed to Fussarium mycotoxins their immune function can be depressed, thus they can be more susceptible to virus or bacterial infections. The addition of dietary nucleotides may increase proliferation of immune cells and optimize the function of the immune system in case of infections.

Keywords

Hrčak ID:

26494

URI

https://hrcak.srce.hr/26494

Publication date:

26.2.2007.

Article data in other languages: croatian

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