Review article

https://doi.org/10.5599/admet.1078

Therapeutic potential of interferon-gamma in tuberculosis

Svetlana A. Berns orcid.org/0000-0003-1002-1895 ; Federal State Institution National Medical Research Center for therapy and Preventive Medicine of the Ministry of Healthcare of the Russian Federation
Julia A. Isakova ; SPP “Pharmaclon” Ltd., Moscow, Russia
Polina I. Pekhtereva orcid.org/0000-0002-2729-9183 ; SPP “Pharmaclon” Ltd., Moscow, Russia

Abstract

Tuberculosis is one of the critical health problems worldwide. The search for ways to improve the results of tuberculosis treatment and overcome drug resistance lies in understanding the pathogenesis of the development of the infectious process. The interferon system, particularly the role of interferon-gamma, has been identified as the main link in the immune response in tuberculosis. The clinical efficacy of interferon-gamma has been studied and evaluated in clinical trials since the end of the last century. There was obtained evidence of the clinical efficacy of interferon-gamma as part of complex therapy. Recent experimental data make it possible to consider interferon-gamma as a promising therapeutic option for the treatment of multidrug-resistant tuberculosis as part of complex therapy worthy of further studies.

Keywords

Interferon gamma; MRD-TB; immunotherapy; IFN-γ; complex treatment.

Hrčak ID:

272938

URI

https://hrcak.srce.hr/272938

Publication date:

14.2.2022.

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