Review article

https://doi.org/10.15644/asc56/1/9

Giant Cell Lesions of the Jaws Involving RASopathy Syndromes

Melissa Luna ; Department of Oral Diagnostic Sciences, University at Buffalo School of Dental Medicine, Buffalo, NY, USA
Nicholas Wolsefer ; Case Western Reserve University School of Dental Medicine, Cleveland, OH, USA
Carlos-Xavier Zambrano ; Case Western Reserve University School of Dental Medicine, Cleveland, OH, USA
Ivan James Stojanov ; Department of Oral and Maxillofacial Medicine and Diagnostic Sciences, Case Western Reserve University, Cleveland, OH, USA; Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA *

* Corresponding author.

Abstract

Objective: Giant cell lesions of the jaws (GCLJ) may rarely occur in the setting of RASopathy syndromes such as Noonan syndrome or neurofibromatosis I. Recently, central giant cell granulomas (CGCG), the most common of the GCLJ, have been recognized as benign neoplasms characterized by Ras/MAPK signaling pathway mutations. This provides a rational basis for understanding GCLJ in RASopathy syndromes as syndromically occurring CGCG. This review aims to summarize the clinico-pathologic features of syndromic CGCG and to review the salient clinical and craniofacial features of the syndromes in which they may rarely occur. Material and Methods: An electronic search in 3 data-bases was performed, looking for GCLJ/CGCG in RASopathy syndromes. Results: 124 CGCG in 56 patients were identified across 6 RASopathy syndromes. Median age at syndromic CGCG diagnosis is 11 years; 69.6% (39/56) patients developed two or more CGCG; 58.9% (33/56) presented with bilateral posterior mandibular CGCGs, mimicking cherubism. Of 88 CGCG with follow-up, 22.4% (13/58) of excised/resected CGCG recurred while 46.7% (14/30) of monitored CGCG showed continued growth. Conclusion: Syndromic CGCG involves multiple RASopathy syndromes and may mimic cherubism or, when solitary, sporadically occurring CGCG. Familiarity with other clinical findings of RASopathy syndromes is critical for appropriate diagnosis and patient management.

Keywords

RASopathy syndromes, central giant cell granuloma, giant cell lesions, Noonan syndrome, neurofibromatosis

Hrčak ID:

274107

URI

https://hrcak.srce.hr/274107

Publication date:

21.3.2022.

Article data in other languages: croatian

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