Original scientific paper
https://doi.org/10.3325/cmj.2021.62.488
Characteristics and clinical outcomes of patients with acute gastrointestinal bleeding related to anticoagulant or antiplatelet therapy: a retrospective study
Dorotea Božić
; Department of Gastroenterology and Hepatology, University Hospital Split, Split, Croatia
Jonatan Vuković
; University of Split, School of Medicine, Split, Croatia
Ivona Mustapić
; Department of Cardiology, University Hospital Split, Split, Croatia
Pavle Vrebalov Cindro
; Department of Gastroenterology and Hepatology, University Hospital Split, Split, Croatia
Joško Božić
; Department of Pathophysiology, University of Split, School of Medicine, Split, Croatia
Goran Kardum
; Faculty of Humanities and Social Sciences, University of Split, Split, Croatia
Željko Puljiz
; Department of Gastroenterology and Hepatology, University Hospital Split, Split, Croatia
Ivana Tadin Hadjina
; Department of Gastroenterology and Hepatology, University Hospital Split, Split, Croatia
Ante Tonkić
; University of Split, School of Medicine, Split, Croatia
Abstract
Aim To investigate the demographic characteristics, endoscopic and laboratory findings, comorbidities and mortality rate of patients with gastrointestinal bleeding related to
anticoagulant or antiplatelet therapy.
Methods We reviewed the records of patients admitted
for gastrointestinal bleeding to the Intensive Care Unit of
the Department of Gastroenterology, University Hospital
Split, between 2015 and 2019. The characteristics and clinical outcomes of patients taking anticoagulant/antiplatelet
therapy were analyzed.
Results The study enrolled 1367 patients, 434 (31.7%) of
whom received anticoagulant/antiplatelet therapy (mean
age 74.9±10.7 years; 64.3% men). The most frequently
prescribed drug was acetylsalicylic acid (56.7%), the most
common bleeding site was the stomach (41.3%), and the
most prevalent cause of bleeding was ulcer (61.6%). Patients taking anticoagulant/antiplatelet therapy who died
had significantly higher creatinine (P=0.011) and lower albumin (P=0.015). In the multivariate analysis, the factors
that negatively affected survival were older age, higher creatinine, and lower albumin. Patients taking anticoagulant/
antiplatelet therapy had slightly lower in-hospital mortality
(8.3%) compared with other patients (10.3%).
Conclusion Although anticoagulant/antiplatelet therapy
increases the risk of gastrointestinal bleeding, it does not
directly affect the outcome, which is mainly determined by
age and comorbidities.
Keywords
Hrčak ID:
278792
URI
Publication date:
21.10.2021.
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